Description

KPV is a naturally occurring tripeptide composed of Lysine-Proline-Valine, derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH). It is widely referenced in laboratory research focused on inflammatory signaling pathways, intestinal epithelial cell response, and immune cell modulation.

Research Focus

• NF-κB and MAP kinase inflammatory signaling pathway inhibition
• PepT1-mediated transport in intestinal epithelial cells
• Pro-inflammatory cytokine response modulation
• Colonic tissue and gut barrier integrity studies
• Immune cell inflammatory response research

Key Research Findings

Published research has demonstrated that KPV at nanomolar concentrations can inhibit activation of NF-κB and MAP kinase signaling pathways, reduce pro-inflammatory cytokine secretion, and is transported into cells via the PepT1 transporter expressed in both immune and intestinal epithelial cells. KPV has also shown a stronger anti-inflammatory effect than its parent molecule α-MSH in certain study models.

Quality and Testing

Each batch is produced for research use and supported by batch level documentation where applicable. Certificate of Analysis and batch specific details should be reviewed prior to use in any research setting.